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GDNF 神經(jīng)膠質(zhì)細(xì)胞源性的神經(jīng)營(yíng)養(yǎng)因子 G-010/050/250

簡(jiǎn)要描述：產(chǎn)品名稱：GDNF 神經(jīng)膠質(zhì)細(xì)胞源性的神經(jīng)營(yíng)養(yǎng)因子
產(chǎn)品編號(hào)：G-010/050/250
品牌；StemRD
廠家：StemRD
產(chǎn)品規(guī)格：10/50/250ug
儲(chǔ)存條件：-80℃
到貨時(shí)間：2-5天

產(chǎn)品型號(hào)：G-010/050/250
廠商性質(zhì)：代理商
更新時(shí)間：2025-02-12
訪問量：1326

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品牌	StemRD/美國(guó)

產(chǎn)品信息

Glial Cell Line-derived Neurotrophic Factor (GDNF) is a disulfide-linked homodimeric glycoprotein. Itis a neurotrophic factor structurally belonging to the TGF-beta super family. The GDNF precursor encodes a 211 amino acid residue prepro-peptide that is processed pro-teolytically to a dimeric mature protein consisting of two 134 amino acid residue subunits.
StemRD's GDNF is made in human 293 cells which renders natural dimerization and human-specific post-translational modifications. We purified this product through a series of chromatography to near homogeneity.

Purity:
Greater than 95% by SDS-PAGE under reducing conditions and visualized by silver staining.

Biological Activity:
The activity was determined by using a Elk-1 luciferase reporter gene assay in 293 cells cotransfected with cRET receptor (Worby, et al. Glial Cell Line-derived Neurotrophic Factor Signals through the RET Receptor and Activates Mitogen-activated Protein Kinase. J Biol Chem. 1996; 271:23619). The EC50ranges from 1 - 10 ng/ml.

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